Epicatechin 250mg High-Strength

Why Methuselah Longevity High Strength Epicatechin:

Single high strength dosing for a longer period of time.
3rd party tested for purity and potency.
Lowest priced per milligram!
Our competitors charge on average between 20%+ more for the same (or lesser) product (see photos for details).
Vegetarian, gluten-free, no artificial colors or flavors, additives or fillers.
Many competitors use non-vegetarian bovine capsules or artificial fillers or coloring.

Product Information:

Servings per container: 120
Epicatechin 250mg
(min. 90% from Camellia Sinensis)

Non-medical ingredients: Microcrystalline Cellulose, Hypromellose (Vegetarian Capsule)

Recommended adult dose:
As a dietary supplement, take 1 to 2 capsules daily after a meal with a glass of water, or as directed by a healthcare practitioner. Consult a physician for use beyond 3 months. Do not use if a seal is broken.

Contains no artificial colors, preservatives, or sweeteners, no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

WARNING: Do not take if you are pregnant or breastfeeding. Consult your healthcare practitioner before using this or with any dietary supplement, especially if you are under medical supervision, taking prescription medication, have allergies or if you suffer from a serious medical condition. Keep out of reach of children.

Epicatechin – The Dark Force Behind Dark Chocolate

What is epicatechin? Epicatechin’s structure looks similar to other known catechins like the popular EGCG from green tea, but it has a whole new batch of benefits and properties

Cocoa extract and several other foods have been found to have a number of bioactive compounds, also known as flavonols, which have a unique ability to improve both health and performance. Of the many flavonols found in the cocoa extract, one particular flavonol known as epicatechin appears to stand head and shoulders above the rest for its health and performance-boosting properties.

Epicatechin is more formally known as (-)-epicatechin, pronounced “minus epicatechin”. It is most prevalent in natural sources of cocoa, ranging from 1.5-2.8mg of epicatechin for every gram of cocoa. The “darker”, more pure, and less processed the chocolate is, the higher the concentration of flavonols inside.

When ingested in efficacious amounts (as discussed in the dosage section below), epicatechin provides benefits such as

increased blood flow and nitric oxide levels,
better insulin sensitivity,
appetite suppression (based on a new study published in August 2016!),
lower cholesterol levels (due to antioxidant activity),
improved blood pressure,
more elastic skin,
and it even has potential anabolic (muscle-building) properties, with possible myostatin-inhibiting abilities!

Each of these benefits is discussed in the benefits section below.

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Therapeutic uses of epicatechin in diabetes and cancer

Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect against a handful of ailments. In this review, we discuss its therapeutic role in the management of two of the most important human diseases; diabetes and cancer. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while its anti-cancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. Although the exact mechanism of action of epicatechin is still being explored, there is no doubt that it is a promising candidate as an alternative. The significance of this review is to highlight the importance of the usage of natural products (in this case, epicatechin) as an alternative for the treatment of two potentially fatal diseases which are diabetes and cancer. The aim of this review is to educate the scientific community on the role of epicatechin in ameliorating the effects of diabetes and cancers on humans while understanding the potential mechanisms of these aforementioned effects.

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Does dark chocolate’s epicatechin content promote muscle growth?

A recent study has revived the supplement market’s interest in a compound called (-)-epicatechin, a molecule found in chocolate. This molecule is claimed to be a myostatin inhibitor. Myostatin deficiencies are well known for their biggest side effect: greatly increased muscle mass without the major side-effects associated with anabolic steroids. Hindering myostatin’s actions would be able to replicate this effect. Myostatin is a myokine, a kind of regulating molecule released by muscles. The ‘opposite’ of myostatin is a myokine called follistatin. Unlike myostatin, which suppresses muscular growth, follistatin indirectly promotes muscle growth because it hinders myostatin signaling.

While there are a few supplements that are known to interact with myostatin signaling (like sulforaphane), none had been tested in the context of human supplementation, until now.

This recent study examined the effects of (-)-epicatechin when supplemented by people.

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3 Benefits of Myostatin Inhibition + Risks & Side Effects

In both humans and animals, myostatin is a hormone that acts as a sort of “brake” that tells muscles to stop growing, which helps to prevent them from getting too large. This is important because past a certain size, adding more mass to muscles doesn’t actually make them stronger – and muscles that are too large are also more vulnerable to damage. Over-developed muscles can also get in the way of other important organs, reducing their size and impairing their functions.

Myostatin is active during multiple stages of the life cycle. Before birth (during embryonic development), myostatin determines the total number of muscle fibers an individual will have.

As an adult, myostatin controls the way that existing muscle fibers grow based on diet, physical activity, and age.

Exercise directly impacts myostatin levels – especially resistance exercise that specifically focuses on increasing muscle strength.

In humans, myostatin levels also often increase with age, which may contribute to the loss of muscle mass during aging.

Myostatin levels are significantly higher in patients with diseases like amyotrophic lateral sclerosis (ALS), Duchenne muscular dystrophy, and multiple sclerosis, which all involve the significant loss of muscle mass. Therefore, inhibiting myostatin may help prevent the loss of muscle in these diseases.

Myostatin is produced by the muscle tissue of the heart, and damage to the heart causes it to be released into the bloodstream. Once in the bloodstream, myostatin reaches the muscles and causes them to weaken over time. As a result, patients with heart disease often also experience symptoms of muscle atrophy (muscle loss).

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