Pterostilbene 250mg High-Strength

Why Methuselah Longevity High Strength Pterostilbene:

• Single high-strength dosing for a longer period of time.
• 3rd party tested for purity and potency.
• Lowest price per milligram!
• Our competitors charge on average between 22-50% more for the same (or lesser) product (see photos for details).
• Vegetarian, gluten-free, no artificial colors or flavors, additives or fillers.
• Many competitors use non-vegetarian bovine capsules or artificial fillers or coloring.

Product Information:

Effect of resveratrol and pterostilbene on aging and longevity.

Over the past years, several studies have found that foods rich in polyphenols protect against age-related diseases, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension, and Alzheimer’s disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds by modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition, and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and high-calorie diets. Moreover, we also discuss the positive effect of resveratrol and pterostilbene on lifespan, age-related disease, and health maintenance. Furthermore, we summarize a variety of important mechanisms modulated by resveratrol and pterostilbene possibly involved in attenuating age-associated disorders. Overall, we describe resveratrol and pterostilbene’s potential for the prevention or treatment of several age-related diseases by modulating age-related mechanisms.

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Pterostilbene May Be better Than Resveratrol

Pterostilbene research suggests it carries an impressive line of benefits ranging from playing roles in fighting cancer, decreasing inflammation, managing diabetes, decreasing the risk of CVD, improving neurological function, helping counter aging processes, and much more. Most of the studies are conducted in lab and animal studies, more human clinical trials are required. However, pterostilbene-rich plants have been used for thousands of years in traditional Chinese and Ayurvedic medicines showing its antioxidant evidence favor. Pterostilbene is a potent free radical scavenger that helps to reduce oxidative stress. Some studies suggest it may mimic the effects of calorie restriction practices that have been shown to increase lifespan and help prevent age-related disorders. Pterostilbene increases levels of another antioxidant called glutathione that helps to improve detoxification and oxidative stress in mitochondria.

Pterostilbene is an anticarcinogenic, several studies suggest that it may be an effective anticancer agent based on its antineoplastic properties that prevent, inhibit, or halt tumor development by altering the cell cycle, inducing apoptosis, and inhibiting metastasis.

Pterostilbene is suggested to offer neuroprotective benefits with its antioxidant properties that help to prevent oxidative stress. Mice studies concluded it may help to preserve cognitive function and reduce the risk of AD in part by reducing inflammation and was associated with slowing the rate of cognitive decline.

A human clinical trial involving 80 subjects with high cholesterol taking 125 mg of pterostilbene twice a day showed significant reductions in blood pressure and minor weight loss. In human and animal studies it helped prevent atherosclerosis by inhibiting the build-up of LDL cholesterol

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Analysis of Safety from a Human Clinical Trial with Pterostilbene

Pterostilbene is a phenol that is chemically related to resveratrol, a possible contributor to the “French Paradox” which associates red wine consumption and lower coronary heart disease. Naturally found in blueberries and grapes, pterostilbene is a phytoalexin, a class of compounds naturally synthesized by plants during pathogen infection. The primary structural difference between pterostilbene and resveratrol is that pterostilbene contains two methoxy groups and one hydroxyl group while resveratrol has three hydroxyl groups. The two methoxy groups cause pterostilbene to be more lipophilic, which increases oral absorption and gives pterostilbene a higher potential for cellular uptake [3]. Pterostilbene has a longer half-life (105 minutes versus 14 minutes) and higher oral bioavailability (80% versus 20%) compared to resveratrol. Pterostilbene also has low total body clearance and subsequent Vss which suggests extensive tissue distribution. Conclusion. Pterostilbene is generally safe for use in humans up to 250 mg/day.

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9 Pterostilbene Health Benefits + Dosage & Side Effects

Pterostilbene vs. Resveratrol
Pterostilbene is part of a class of compounds called phytoalexins: in plants, these compounds defend against microbes and parasites. It is very similar to a better-known phytoalexin antioxidant, resveratrol. However, pterostilbene is about four times easier to absorb from the gut into the body; in theory, that could make it multiple times more effective than resveratrol. Snapshot – Open to view in detailed analysis.

PROs:
Helps fight against cancer;
Improves cognition and prevents cell death in the brain;
Reduces blood sugar;
Reduces inflammation;
Lowers blood pressure;
Protects the liver, heart, and eyes;
Supports weight loss programs;

Cons:
Can increase LDL cholesterol – can be negated with Grape Seed extract;
Drug interactions are possible;
Few human studies.

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