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Methuselah Longevity

Cutting-Edge Longevity Supplements

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Key Benefits*

  • Naturally increases NAD+ levels in the body. By inhibiting a key enzyme that destroys NAD+ in the body (CD38) Apigenin promotes a natural increase in NAD+, an important coenzyme central to metabolism and life extension.
  • Apigenin Prevents Heart Damage. Apigenin prevents heart enlargement and tissue scarring due to high blood pressure or clogged arteries in recent experiments.
  • Apigenin aids in countering oxidative stress. Animal studies suggest that apigenin may impede genetic mutations occurring in cells that are exposed to toxins and bacteria. Apigenin may also play direct roles in the removal of free radicals, inhibition of tumor growth enzymes, and induction of detoxification enzymes such as glutathione.

* All individuals are unique. Your results may vary.

Why Choose Methuselah Longevity High-Strength Apigenin:

  • Single high-strength dosing for a longer period of time.
  • 3rd party tested for purity and potency.
  • Lowest price per milligram!
  • Our competitors charge on average between 17% or more for the same (or less) amount of product (see table).
  • Vegetarian, gluten-free, no artificial colors or flavors.

Product Information:

Apigenin 250mg
(min. 98% from Citrus Aurantium)


Serving Size 1 veggie capsule
Servings per container 90

Non-medical ingredients: Microcrystalline Cellulose, Hypromellose (Vegetarian Capsule).

Recommended adult dose:
As a dietary supplement, take 1 capsule daily with a glass of water, or as directed by a healthcare practitioner. Consult a physician for use beyond 3 months. Do not use if a seal is broken.

Contains no artificial colors, preservatives, or sweeteners, no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

Warning: Do not take if you are pregnant or breastfeeding. Consult your healthcare practitioner before using this or any dietary supplement, especially if you are under medical supervision, taking prescription medication, have allergies, or if you suffer from a serious medical condition. Keep out of reach of children.


Apigenin in Science Press


fruit marketApigenin: An Alternative Way of Boosting NAD+

At the recent Ending Age-Related Diseases 2021 online conference, Dr. Eric Verdin of the Buck Institute gave a talk in which he described the mechanism behind the well-known drop in NAD+ with age, for which lots of anti-aging folks are spending significant $ taking NR or NMN, with very limited results in humans.  Verdin attributed the NAD+ loss to a rise with age of an enzyme called CD38, which destroys the NAD+, removing it from the normal cycle.  It turns out that the readily available flavonoid Apigenin is an inhibitor of CD38.



Apigenin is a flavone (a subclass of bioflavonoids) primarily found in plants. It is frequently extracted from the plant Matricaria recutita L (chamomile), a member of the Asteraceae (daisy) family. In foods and herbs, apigenin is often found in the more stable derivative form of apigenin-7-O-glucoside.


Natural Antioxidant Apigenin Prevents Cardiac Damage, Scientists Find.

Overall, the findings of Xu and colleagues suggest that apigenin can prevent damage and remodeling (enlargement) of the heart by countering oxidative stress. Previous animal studies, including one that used gold particles covered in apigenin, corroborate the cardioprotective effects of apigenin. Furthermore, a human epidemiological study showed that a diet rich in apigenin is associated with a reduced risk of coronary heart disease.  Apigenin can be found in various foods as well as chamomile tea. It also comes in supplement form, although the authors mention that apigenin is not water-soluble, potentially making it less bioavailable.



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