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Methuselah Longevity

Cutting-Edge Longevity Supplements

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Key Benefits*

  • Helps control weight and blood pressure. Pterostilbene has shown some mild weight loss as well as improved gut flora.
  • Powerful anti-oxidant. Pterostilbene increases antioxidant enzymes in the body as well as SIRT1, a signaling pathway that protects against cellular damage and aging.
  • Strong neuroprotective abilities aid cognition and memory. In studies, pterostilbene has shown neuroprotective abilities, and boosted brain dopamine levels as well as working memory. Pterostilbene also protects neurons against a specific type of damage associated with Alzheimer’s disease.
  • It May help control blood sugar & blood pressure. Improved insulin sensitivity and healthier gut flora increasing protection from obesity and diabetes have been observed.
  • Antioxidant benefits to the liver, heart, and eyes. Cellular protection from oxidative stress has been noted in several studies of liver, heart, and eye health.

* All individuals are unique. Your results may vary.

Why Methuselah Longevity High Strength Pterostilbene:

  • Single high-strength dosing for a longer period of time.
  • 3rd party tested for purity and potency.
  • Lowest price per milligram!
  • Our competitors charge on average between 22-50% more for the same (or lesser) product (see photos for details).
  • Vegetarian, gluten-free, no artificial colors or flavors, additives or fillers.
  • Many competitors use non-vegetarian bovine capsules or artificial fillers or coloring.

Product Information:

Servings per container: 90
Pterostilbene 250mg
(min. 99% from Vaccinium uliginosum)
Non-medical ingredients: Microcrystalline Cellulose, Hypromellose (Vegetarian Capsule)
Recommended adult dose:
As a dietary supplement, take 1 capsule daily after a meal with a glass of water, or as directed by a healthcare practitioner. Consult a physician for use beyond 3 months. Do not use it if a seal is broken.
Contains no artificial colors, preservatives, or sweeteners, no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.
WARNING: Do not take if you are pregnant or breastfeeding. Consult your healthcare practitioner before using this or any dietary supplement, especially if you are under medical supervision, taking prescription medication, have allergies, or if you suffer from a serious medical condition. Keep out of reach of children.


Pterostilbene in Science Press

Effect of resveratrol and pterostilbene on aging and longevity.

Over the past years, several studies have found that foods rich in polyphenols protect against age-related diseases, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension, and Alzheimer’s disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds by modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition, and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and high-calorie diets. Moreover, we also discuss the positive effect of resveratrol and pterostilbene on lifespan, age-related disease, and health maintenance. Furthermore, we summarize a variety of important mechanisms modulated by resveratrol and pterostilbene possibly involved in attenuating age-associated disorders. Overall, we describe resveratrol and pterostilbene’s potential for the prevention or treatment of several age-related diseases by modulating age-related mechanisms.


Pterostilbene May Be better Than Resveratrol

blueberriesPterostilbene research suggests it carries an impressive line of benefits ranging from playing roles in fighting cancer, decreasing inflammation, managing diabetes, decreasing the risk of CVD, improving neurological function, helping counter aging processes, and much more. Most of the studies are conducted in lab and animal studies, more human clinical trials are required. However, pterostilbene-rich plants have been used for thousands of years in traditional Chinese and Ayurvedic medicines showing its antioxidant evidence favor. Pterostilbene is a potent free radical scavenger that helps to reduce oxidative stress. Some studies suggest it may mimic the effects of calorie restriction practices that have been shown to increase lifespan and help prevent age-related disorders. Pterostilbene increases levels of another antioxidant called glutathione that helps to improve detoxification and oxidative stress in mitochondria.

Pterostilbene is an anticarcinogenic, several studies suggest that it may be an effective anticancer agent based on its antineoplastic properties that prevent, inhibit, or halt tumor development by altering the cell cycle, inducing apoptosis, and inhibiting metastasis.

Pterostilbene is suggested to offer neuroprotective benefits with its antioxidant properties that help to prevent oxidative stress. Mice studies concluded it may help to preserve cognitive function and reduce the risk of AD in part by reducing inflammation and was associated with slowing the rate of cognitive decline.

A human clinical trial involving 80 subjects with high cholesterol taking 125 mg of pterostilbene twice a day showed significant reductions in blood pressure and minor weight loss. In human and animal studies it helped prevent atherosclerosis by inhibiting the build-up of LDL cholesterol


Analysis of Safety from a Human Clinical Trial with Pterostilbene

Pterostilbene is a phenol that is chemically related to resveratrol, a possible contributor to the “French Paradox” which associates red wine consumption and lower coronary heart disease. Naturally found in blueberries and grapes, pterostilbene is a phytoalexin, a class of compounds naturally synthesized by plants during pathogen infection. The primary structural difference between pterostilbene and resveratrol is that pterostilbene contains two methoxy groups and one hydroxyl group while resveratrol has three hydroxyl groups. The two methoxy groups cause pterostilbene to be more lipophilic, which increases oral absorption and gives pterostilbene a higher potential for cellular uptake [3]. Pterostilbene has a longer half-life (105 minutes versus 14 minutes) and higher oral bioavailability (80% versus 20%) compared to resveratrol. Pterostilbene also has low total body clearance and subsequent Vss which suggests extensive tissue distribution. Conclusion. Pterostilbene is generally safe for use in humans up to 250 mg/day.


9 Pterostilbene Health Benefits + Dosage & Side Effects

pale blueberriesPterostilbene vs. Resveratrol
Pterostilbene is part of a class of compounds called phytoalexins: in plants, these compounds defend against microbes and parasites. It is very similar to a better-known phytoalexin antioxidant, resveratrol. However, pterostilbene is about four times easier to absorb from the gut into the body; in theory, that could make it multiple times more effective than resveratrol. Snapshot – Open to view in detailed analysis.

Helps fight against cancer;
Improves cognition and prevents cell death in the brain;
Reduces blood sugar;
Reduces inflammation;
Lowers blood pressure;
Protects the liver, heart, and eyes;
Supports weight loss programs;

Can increase LDL cholesterol – can be negated with Grape Seed extract;
Drug interactions are possible;
Few human studies.


28 reviews for Pterostilbene 250mg High-Strength

  1. Claire S

    Like the dosage and price, thanks!

  2. Renaldo

    fast shipping, quality product

  3. Sue

    After only one or two days of taking Pterostilbene, I was pleased to find myself concentrating and focusing better. Best of all, I felt motivated to start a couple of projects that I have been avoiding for some. I will definitely be taking Pterostilbene on a daily basis.

  4. Marco

    Thank you for the great customer service in replacing a missing package, much appreciated! 10/10

  5. KC

    Great product, great price. Gives me get up and go energy when I need it. I like how I’m able to stay alert without fatigue throughout the day.

  6. Solomediag

    I’ve been taking these for a couple months. The biggest effect, which I noticed right away, is that I sleep better. Maybe they help to regulate my metabolism. They don’t have me bursting with energy or anything, but they do seem to ward off brain fog. That could just be a result of sleeping more soundly, but it’s worth what it costs to take one of these a day.

  7. Minhal

    Good price and dosage. Free shipping did take a month to arrive.

  8. Matt (verified owner)

    UPS shipping option was very fast and the product definitely works, much thanks!

  9. Kjersti Hegelstad (verified owner)

  10. Robert Rhodes (verified owner)

    A repeat of what I said below

  11. Anonymous (verified owner)

  12. Erlend Taule (verified owner)

    Rask og problemfri levering da varene først kom på lager. Godt produkt.

  13. Anonymous (verified owner)

  14. Peter (verified owner)

    This product is of unmatched quality, I’m taking it every day and it’s working beautifully. I live in Australia and receive a wonderful reliable service from Methuselah every time- highly recommended this company!

  15. ARNHILD (verified owner)

    good quality product. good value.

  16. Peder (verified owner)

    Another great antioxidant that works well with NMN

  17. Margaret Troxell (verified owner)


  18. Anonymous (verified owner)


  19. Peter (verified owner)

    This is by far the best and most potent Pterostilbene I know, that is why I keep ordering it again and again enjoying the great reliable service coming with it.

  20. Anonymous (verified owner)

    It’s well tolerated by me

  21. Margaret Troxell (verified owner)


  22. Peter Erker (verified owner)

    I’m taking Methuselah supplements for quite some time now and can honestly say the quality of their products is unsurpassed and the service is outstanding, I highly recommend them.

  23. Anonymous (verified owner)


  24. Peder (verified owner)

    Real powerful antioxidant!

  25. Cornelia Velders (verified owner)


  26. Verified Buyer (verified owner)

    Good quality:)

  27. Peter E. (verified owner)

    Who ever takes Pterostilbene…don’t go past this amazing product from Methuselah it’s in a class of its own not only the most potent one as quality is matched by outstanding service!

  28. Anonymous (verified owner)


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