Powerful life extension support. NAD+ is involved in a vast array of functions, from cell division to DNA repair. Replenishing these levels through NMN is theorized to be a key to preventing age-related decline in the body.
Increases SIRT gene activity. Sirtuins combat oxidative stress, DNA damage, and cellular aging. Low sirtuins levels have been linked to aging and aging-related diseases, while high sirtuins enhance fertility in women.
Increases telomere length. Animal studies have shown increased telomere length. Telomeres are long “tails” of repeating DNA code at the ends of chromosomes. Every time a chromosome duplicates itself, it loses some of its telomeres; thus, as the organism ages, telomeres shorten, eventually leading to cell death.
Improves energy levels. NAD increases the body’s main energy currency (ATP), balances the circadian rhythm, and enables hundreds of enzymatic reactions – many of which delay aging.
Brain health. Animal studies showed NMN had drastically improved blood flow to their brains. As poor blood flow is a major risk factor in hypertension, Alzheimer’s disease, and stroke, this result bodes well for NMN’s impact on these diseases.NMN also reduced β-amyloid plaque levels in the brains of diseased mice, a major risk factor of Alzheimer’s disease.
* All individuals are unique. Your results may vary.
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- World’s first high-strength NMN supplement.
- Methuselah Longevity is proud to release the world’s first high-strength NMN.
- In most animal studies that showed significant positive health effects, the human equivalent dose (HED) was 500 mg. Almost every other supplement on the market offers 300 mg (or less) per serving.
- One of the premier researchers in the field, Professor David Sinclair, also takes 500 mg serving (see “Stunning anti-aging breakthrough could see humans live to 150 and regenerate organs by 2020 ‘for the price of a coffee a day”)
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- Our competitors charge on average between 10-40% more for the same (or lesser) product (see photos for details).
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NMN in Science Press
Harvard scientists unveil a giant leap for anti-ageing.
“They had already established that NAD+ could be useful for treating various diseases of aging, female infertility, and also treating side effects of chemotherapy.
In a paper published in Science today, the Harvard-led team identifies a critical step in the molecular process that allows cells to repair damaged DNA.
Their experiments in mice suggest a treatment is possible for DNA damage from aging and radiation. It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission.”
Is this pink pill the elixir of youth?
A Harvard scientist claims NMN drug has already knocked 20 years off his age – and given his 77-year-old father the energy of a 30-year-old. The NMN pill could be key in reversing the effects of aging.
“In the body, NMN is converted into a related chemical called nicotinamide adenine dinucleotide (NAD), which is found in every cell of living organisms and is essential for life. NAD is crucial in fuelling the seven different genes in our body that govern aging.
However, our NAD levels decline by about 50 percent as we age, turning off the body’s defenses against aging and age-related diseases such as cancer, diabetes, heart disease, and Alzheimer’s.
They will be monitored closely by the U.S. space agency NASA, which is interested in using the drug during future missions to Mars to stop the accelerated aging process that affects astronauts exposed to radiation in space.
Professor Sinclair is so convinced of his pill’s safety that not only has he been taking it himself, so has his 77-year-old father.
The results certainly sound encouraging. Before he started taking a 500mg NMN pill every morning, 47-year-old Professor Sinclair had his blood tested and was told his body had a biological age of 58.
After consuming NMN for three months, he was tested again and his biological age was 32.
As for his father, he’s recently been out-pacing the professor’s younger brother on mountaineering expeditions in their native Australia.
‘He’s as vigorous as he was in his 20s and 30s, and he seems to be getting more energetic,’ says Professor Sinclair.”
What NMN does, Sinclair says, is provide the same benefits in improving blood flow that exercise does by promoting a family of molecules called sirtuins. “Here we have the potential of having a pill give the benefits of basically running for 10 miles a day without having to do that,” he says. That can be especially important for older people who are physically unable to exercise as much as they should. “It’s not just about trying to replace exercise when you are middle-aged, but giving you the benefits of exercise when you are too old to be able to do it.”
Is an Anti-Aging Pill on the Horizon?
“A group of researchers believes they’re getting closer, however, thanks to a compound called nicotinamide adenine dinucleotide, or NAD+ for short.
“NAD+ is the closest we’ve gotten to a fountain of youth,” says David Sinclair, co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. “It’s one of the most important molecules for life to exist, and without it, you’re dead in 30 seconds.”
NAD+ is a molecule found in all living cells and is critical for regulating cellular aging and maintaining the proper function of the whole body. Levels of NAD+ in people and animals diminish significantly over time, and researchers have found that re-upping NAD+ in older mice causes them to look and act younger, as well as live longer than expected.”
NAD+ Repletion Shows Potential Against Aging
“In just a week, some signs of aging in muscle and other tissues had been reversed so much so that the researchers could no longer tell the difference between these 2-year-old mice (70-year-old human equivalent) and the tissues of 4-month-old mice (26-year-old human equivalent).
In a broad sense, NMN improves blood flow in the same way that exercise does, as it interacts with a family of molecules called sirtuins. This means that if NMN works as hoped, it would be an exercise mimetic, and using it would have similar benefits to actual exercise; this could be useful for older people who are already suffering from loss of mobility and cannot exercise. It also has potential as a preventative for vascular aging in general and for improving tissue regeneration and wound healing.”
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
“Although the reason NAD+ declines with age is unclear, this work provides a plausible explanation for why DNA repair capacity declines as we age (24), pointing to NAD+ replenishment as a means of reducing the side effects of chemotherapy, protecting against radiation exposure, and slowing the natural decline in DNA repair capacity during aging.”
Stunning anti-ageing breakthrough could see humans live to 150 and regenerate organs by 2020 ‘for the price of a coffee a day.
A new technique could see the aging process in humans reduced by 50 years
Researchers from Sydney found mice given the pill lived ten percent longer
The molecule could also regenerate certain organs by reprogramming their cells
The drug could be available to the public in five years following human testing
“The science behind the new technique involves the molecule nicotinamide adenine dinucleotide (NAD), which plays a role in generating energy in the human body.
The chemical is already used as a supplement for treating Parkinson’s disease and fighting jet lag.
Professor Sinclair, who is using his own molecule to reduce the aging process, said his biological age has dropped by 24 years after taking the pill.
He said his father, 79, has been white water rafting and backpacking after starting using the molecule a year-and-a-half ago.
The professor also said his sister-in-law was now fertile again after taking the treatment, despite having started to transition into menopause in her 40s.”
Scientists identify new fuel-delivery route for cells.
“With age, cells gradually lose their ability to take in and process fuel. A cell that can’t fill its fuel tank, so to speak, can’t perform its proper functions. Researchers are interested in finding ways to boost the energy supply of aging cells in an effort to stave off the detrimental effects of the inevitable passage of time.
A key element of any cell’s fuel supply chain is a molecule called nicotinamide adenine dinucleotide (NAD). Past work has shown that NAD levels in tissues throughout the body decrease with age. One way cells manufacture NAD begins with a precursor molecule called nicotinamide mononucleotide (NMN), which is found naturally in foods such as edamame, broccoli, cabbage, cucumber, and avocado.
What may be important in a future strategy is the combination of giving NMN along with stimulating the transport of NMN into cells,” Imai said. “With aging, we see a bottleneck in NAD production. The body loses its ability to manufacture NAD over time. At the same time, it seems to begin burning more NAD, likely due to chronic inflammation. If we can give NMN and aid its transport into cells, that may be a way to bypass the bottleneck.”