Stimulates the growth of new mitochondria. Greater mitochondrial damage has been found in brain cells of humans over 70 relative to those in their early 40s. Many scientists believe mitochondrial longevity and the number of functioning mitochondria determine overall human longevity. The coenzyme PQQ has been shown to induce mitochondrial biogenesis—the growth of new mitochondria in aging cells.
Superior Anti-Oxidant. Providing powerful antioxidant support to mitochondria and other body molecules—with up to 5,000 times the effect of other antioxidants, and protecting the brain’s cells and neurotransmitter systems against neurotoxicity and amyloid-beta protein.
Improves energy level. PQQ stimulates the growth of new mitochondria in aging cells, which are cellular power producers, responsible for almost all biochemical energy production.
Provides mitochondrial protection and repair. Recent rodent research on gene expression has shown that an induced deficiency of the coenzyme pyrroloquinoline quinone, or PQQ, results in an altering of the expression of a total of 438 genes.
* All individuals are unique. Your results may vary.
Why Methuselah Longevity High Strength Pyrroloquinoline Quinone:
- Single high-strength dosing for a longer period of time.
- 3rd party tested for purity and potency.
- Lowest price per milligram!
- Our competitors charge on average between 5-60% more for the same (or lesser) product (see photos for details).
- Vegetarian, gluten-free, no artificial colors or flavors.
Recommended adult dose:
As a dietary supplement, take 1 capsule daily after a meal with a glass of water, or as directed by a healthcare practitioner. Consult a physician for use beyond 3 months. Do not use it if a seal is broken.
PQQ in Science Press
Powerful Protection Against Cellular Aging
A critical coenzyme known as PQQ activates vital cell-signaling pathways involved in creating new mitochondria, improving cellular metabolism, protecting neurons, and repairing DNA damage. PQQ has the potential to reverse subcellular aging!
How can PQQ target multiple aging factors? The answer lies in the potent and unique capacity of PQQ to activate cell signaling pathways, especially those directly involved in cellular energy metabolism. Also, similar to the action of CoQ10, PQQ actively participates in the energy transfer within the mitochondria that supplies the body with most of its bioenergy.PQQ can even trigger spontaneous mitochondrial biogenesis—the creation of fresh, new mitochondria! Specific cell signaling molecules have been found to be directly activated by PQQ.
By Michael Downey, Health & Wellness Author.
Recent progress in studies on the health benefits of pyrroloquinoline quinone.
“Recent progress in studies on the health benefits of pyrroloquinoline quinone PQQ has been shown to be a ubiquitous molecule that influences a multitude of physiological and biochemical processes. In this review, we have presented recent studies supporting the role of PQQ in maintaining and improving human health. There are potential benefits from PQQ supplementation related to lipidemic and glycemic control, prevention of cardiovascular and neurodegenerative diseases, and improvement of brain functions. Recent evidence suggests that PQQ can be useful for various health benefits through different mechanisms including redox activity, radical-scavenging activity, and modulation of cell signaling pathways. According to recent observations, PQQ shows no toxicity and genotoxicity in oral administration, and thus, oral supplementation of PQQ would be a promising approach to improving health status. On the other hand, the precise molecular mechanism underlying the action of PQQ is not understood fully. The mechanistic studies that aid in defining the function of PQQ could provide further benefits for human health.”
By Mitsugu Akagawa, Masahiko Nakano & Kazuto Ikemoto for Bioscience, Biotechnology, and Biochemistry
PQQ for mental and physical fitness.
“PQQ promotes a process known as mitochondrial biogenesis, in which mitochondria divide and multiply. In an animal study, PQQ was shown to stimulate mitochondrial production at a rate of 500 to 1,000 times higher than other ingredients shown to support mitochondrial function. PQQ also appears to enhance a protein called nerve growth factor (NGF), which is composed of 118 amino acid residues that help regulate the growth, maintenance, proliferation, and survival of certain target neurons. Several studies indicate that PQQ potentially stimulates NGF and may help with growth and recovery of damaged nerves and organs.”
By Shoji Matsukawa for Natural Products Insider.
PQQ May Reduce the Risk of Heart Failure, Says New Animal Study.
“For the first time ever, the positive benefits of the powerful antioxidant PQQ on myocardial mitochondrial dysfunction and chronic heart failure have been demonstrated,” said Thomas Schrier, vice president of sales at Nascent Health Sciences, in a statement. “The researchers at Nantong University were specifically looking for treatment options to target mitochondrial function in the heart and have now found conclusive evidence that PQQ’s ability to stimulate mitochondrial biogenesis can prevent cardiac damage and promote heart health.”
By Sebastian Krawiec for Nutritional Outlook.
Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep.
More than 1,000 studies, including animal and human clinical trials, have been conducted on PQQ to measure its effectiveness and safety. A randomized, placebo-controlled, and double-blinded study on 41 healthy elderly subjects who were each administered 20 mg/d of the ingredient for 12 weeks. The study showed significant improvements in subjects administered PQQ based on assessments measuring selective attention and visual-spatial cognitive functioning. Another eight-week study on 17 adult female subjects administered 20 mg of PQQ daily showed significant improvements in measurements for vigor, fatigue, tension-anxiety, depression, anger-hostility, and confusion.