Fisetin 200mg High-Strength
Potent Senolytic for Healthy Aging - Fisetin 200mg
$69.00
Fisetin is a flavonol belonging to the flavonoid group of polyphenols, under active scientific investigation for its anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties. Research has shown that fisetin can remove senescent cells from aged mice, improving health and lifespan, and is currently considered the strongest potential senolytic agent yet discovered. Naturally present in many fruits and vegetables, fisetin has been demonstrated safe, even at high doses, with no reported adverse effects. Supplementing with fisetin may support healthy aging, making it an excellent choice—even for elderly individuals.
NOTE: Product is not shipping to Canada, pending NHP listing.
Nature’s most powerful senolytic agent. Aging is characterized by the buildup of senescent cells – cells that stop dividing, become damaged, and start releasing inflammatory molecules. Fisetin is the most effective natural compound to date, helping to remove these senescent cells, improving physical function, and potentially increasing lifespan. Animal tests to date have shown a 10-20% increased lifespan.
Powerful diabetic support. Through various mechanisms, Fiestin helps control blood sugar as well as kidney and liver health.
Potential anticancer properties. Numerous studies have shown antitumor as well as anti-inflammatory properties.
Neuroprotective. Fisetin supplementation has shown improved memory as well as better mood (through increased serotonin and noradrenaline levels).
Heart Health. Fisetin has shown improved blood circulation as well as decreased high cholesterol levels.
* All individuals are unique. Your results may vary.
Fisetin May Be a Low-Hanging Fruit for Aging
University of Minnesota Medical School faculty member Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia recently published “Fisetin is a senotherapeutic that extends health and lifespan” in the journal EBioMedicine [3]. During their study, they discovered that fisetin was able to remove senescent cells from aged mice, which improved their health and lifespan.
This flavonoid is a natural compound present in many fruits and vegetables such as apples, persimmon, grapes, onions, cucumbers, and strawberries, suggesting that it is imminently translatable. Importantly, no adverse effects of fisetin have been reported, even when given at high doses. Thus, our results suggest that supplementation or even intermittent treatment with this safe, natural product could improve healthy aging, even in elderly individuals.
Given that we have known about fisetin for some time and there have been various studies showing that it has anti-inflammatory and neuroprotective properties in animals, you might be wondering why are we only just now hearing so many things about it.
The researchers also compared fisetin against other compounds, including resveratrol, luteolin, rutin, epigallocatechin gallate, curcumin, pirfenidone, myricetin, apigenin, and catechin. This study showed that fisetin was the most effective of these compounds.
13 Amazing Fisetin Benefits + Foods, Dosage & Side Effects
Fisetin is a flavonol, a yellow plant pigment that belongs to the flavonoid group of polyphenols. It gives color to many different fruits and vegetables [1, 2].
Compared to now-famous plant antioxidants like resveratrol and quercetin, fisetin was unfairly ignored for far too long. It wasn’t until recent years that researchers became increasingly interested in its medicinal potential.
Science teams are currently exploring its ability to slow the aging process and extend lifespan–it’s so-called “senolytic” effects. What’s more, fisetin has powerful anti-inflammatory, antioxidant, and anti-cancer properties [3, 4].
Despite promising animal and cell-based findings, research is still in its early stages.
Fisetin Acts on Multiple Pathways to Reduce the Impact of Age and Disease on CNS Function
It is becoming increasingly clear that neurological diseases are multi-factorial involving disruptions in multiple cellular systems. Thus, while each disease has its own initiating mechanisms and pathologies, certain common pathways appear to be involved in most, if not all, neurological diseases described to date.
Over the last few years, we have identified an orally active, novel neuroprotective and cognition-enhancing molecule, the flavonoid fisetin. Fisetin not only has direct antioxidant activity but it can also increase the intracellular levels of glutathione, the major intracellular antioxidant. Fisetin can also activate key neurotrophic factor signaling pathways. In addition, it has anti-inflammatory activity against microglial cells and inhibits the activity of lipoxygenases, thereby reducing the production of pro-inflammatory eicosanoids and their by-products. This wide range of actions suggests that fisetin has the ability to reduce the impact of age-related neurological diseases on brain function.
Animal Data Shows Fisetin to be a Surprisingly Effective Senolytic
As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person’s immune system is healthy and is able to clear the damaged cells. But as people age, they aren’t cleared as effectively. Thus they begin to accumulate, cause low-level inflammation and release enzymes that can degrade the tissue.
Researchers found a natural product, called fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and seeing improvement in health and lifespan. “These results suggest that we can extend the period of health, termed healthspan, even towards the end of life.
The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways
Digestive cancers are a major cause of mortality and morbidity worldwide. Fisetin, a naturally occurring flavonoid, has been previously shown anti-proliferative, anti-cancer, neuroprotective, and antioxidant activities. In our study, the anti-tumor activities in addition to the regulatory effects of fisetin on some cancer cell lines were investigated. Data presented here showed that fisetin induces growth inhibition, and apoptosis in hepatic (HepG-2), colorectal (Caco-2), and pancreatic (Suit-2) cancer cell lines.
