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High Strength Pterostilbene 250mg – Back in stock early Oct!

(7 customer reviews)

USD $47.00

Pterostilbene is a naturally occuring analogue to resveratrol. While most of the actions of the two are comparable, pterostilbene appears to be much more well absorbed following oral ingestion and may be a more potent antioxidant and anticancer molecule.  Pterostilbene differs from resveratrol by exhibiting increased bioavailability, 80% compared to 20% in resveratrol.

“Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer’s disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence.” – Effects of reseveratrol and pterostilbene on aging and longevity., Li et al, 2018.

*Product currently is not shipping to Canada, pending NHP listing.

Out of stock

Category:
Why Methuselah Longevity High Strength Pterostilbene:
  • Single high strength dosing for a longer period of time.
  • 3rd party tested for purity and potency.
  • Lowest priced per milligram!
  • Our competitors charge on average between 22-50% more for the same (or lesser) product (see photos for details).
  • Vegetarian, gluten-free, no artificial colors or flavors, additives or fillers.
    • Many competitors use non-vegetarian bovine capsules or artificial fillers or coloring.
Product Information:
Servings per container: 90
Pterostilbene 250mg
(min. 99% from Vaccinium uliginosum)
Non-medical ingredients: Microcystalline Cellulose, Hypromellose (Vegetarian Capsule)
Recommended adult dose:
As a dietary supplement, take 1 capsule daily after meal with a glass of water, or as directed by a healthcare practitioner. Consult a physician for use beyond 3 months. Do not use if a seal is broken.
Contains no artificial colors, preservatives, or sweeteners, no dairy, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.
Warning: Do not take if you are pregnant or breastfeeding. Consult your healthcare practitioner before using this or with any dietary supplement, especially if you are under medical supervision, taking prescription medication, have allergies or if you suffer from a serious medical condition. Keep out of reach of children.

Effect of resveratrol and pterostilbene on aging and longevity.

Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer’s disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and high-calorie diets. Moreover, we also discuss the positive effect of resveratrol and pterostilbene on lifespan, aged-related disease, and health maintenance. Furthermore, we summarize a variety of important mechanisms modulated by resveratrol and pterostilbene possibly involved in attenuating age-associated disorders. Overall, we describe resveratrol and pterostilbene potential for prevention or treatment of several age-related diseases by modulating age-related mechanisms.

Pterostilbene May Be better Than Resveratrol

Pterostilbene research suggests it to carry an impressive line of benefits ranging from playing roles in fighting cancer, decreasing inflammation, managing diabetes, decreasing risk of CVD, improve neurological function, help counter aging processes, and much more. Most of the studies are conducted in lab and animal studies, more human clinical trials are required. However pterostilbene rich plants have been used for thousands of years in traditional Chinese and Ayurvedic medicines showing its antioxidant evidence favor.Pterostilbene is a potent free radical scavenger that helps to reduce oxidative stress. Some studies suggests it may mimic effects of calorie restriction practices that have been shown to increase lifespan and help prevent age related disorders. Pterostilbene increases levels of another antioxidant called glutathione that helps to improve detoxification and oxidative stress in mitochondria.

Pterostilbene is an anticarcinogenic, several studies suggest that it may be an effective anticancer agent based on its antineoplastic properties that prevent, inhibit, or halt tumor development by altering cell cycle, inducing apoptosis, and inhibiting metastasis.

Pterostilbene is suggested to offer neuroprotective benefits with its antioxidant properties that help to prevent oxidative stress. Mice studies concluded it may help to preserve cognitive function and reduce risk of AD in part by reducing inflammation, and was associated with slowing the rate of cognitive decline.

Human clinical trial involving 80 subjects with high cholesterol taking 125 mg of pterostilbene twice a day showed significant reductions in blood pressure, and minor weight loss. In human and animal studies it helped prevent atherosclerosis by inhibiting build up of LDL cholesterol.

Analysis of Safety from a Human Clinical Trial with Pterostilbene

Pterostilbene is a phenol that is chemically related to resveratrol, a possible contributor to the “French Paradox” which associates red wine consumption and lower coronary heart disease. Naturally found in blueberries and grapes, pterostilbene is a phytoalexin, a class of compounds naturally synthesized by plants during pathogen infection. The primary structural difference between pterostilbene and resveratrol is that pterostilbene contains two methoxy groups and one hydroxyl group while resveratrol has three hydroxyl groups. The two methoxy groups cause pterostilbene to be more lipophilic, which increases oral absorption and gives pterostilbene a higher potential for cellular uptake [3]. Pterostilbene has a longer half-life (105 minutes versus 14 minutes) and higher oral bioavailability (80% versus 20%) compared to resveratrol. Pterostilbene also has low total body clearance and subsequent Vss which suggests extensive tissue distribution.Conclusion. Pterostilbene is generally safe for use in humans up to 250 mg/day.

9 Pterostilbene Health Benefits + Dosage & Side Effects

Pterostilbene vs. Resveratrol
Pterostilbene is part of a class of compounds called phytoalexins: in plants, these compounds defend against microbes and parasites. It is very similar to a better-known phytoalexin antioxidant, resveratrol. However, pterostilbene is about four times easier to absorb from the gut into the body; in theory, that could make it multiple times more effective than resveratrol.Snapshot – Open to view in detailed analysis.PROs
Helps fight against cancer
Improves cognition and prevents cell death in the brain
Reduces blood sugar
Reduces inflammation
Lowers blood pressure
Protects the liver, heart, and eyes
Supports weight loss programsCONs
Can increase LDL cholesterol – can be negated with Grape Seed extract.
Drug interactions are possible
Few human studies

7 reviews for High Strength Pterostilbene 250mg – Back in stock early Oct!

4.8
Based on 6 reviews
5 star
83%
4 star
16%
3 star
0%
2 star
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1 star
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  1. qzgi3htydqLe

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  2. Claire S

    Like the dosage and price, thanks!

  3. Renaldo

    fast shipping, quality product

  4. Sue

    After only one or two days of taking Pterostilbene, I was pleased to find myself concentrating and focusing better. Best of all, I felt motivated to start a couple of projects that I have been avoiding for some. I will definitely be taking Pterostilbene on a daily basis.

  5. Marco

    Thank you for the great customer service in replacing a missing package, much appreciated! 10/10

  6. KC

    Great product, great price. Gives me get up and go energy when I need it. I like how I’m able to stay alert without fatigue throughout the day.

  7. Solomediag

    I’ve been taking these for a couple months. The biggest effect, which I noticed right away, is that I sleep better. Maybe they help to regulate my metabolism. They don’t have me bursting with energy or anything, but they do seem to ward off brain fog. That could just be a result of sleeping more soundly, but it’s worth what it costs to take one of these a day.

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